| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 26-09-25 19:00 | FC Twente Enschede | Fortuna Sittard | 3:2 |
| 27-09-25 15:30 | Ajax Amsterdão | NAC Breda | 2:1 |
| 27-09-25 17:45 | FC Volendam | PEC Zwolle | 2:1 |
| 27-09-25 19:00 | Excelsior Roterdão | PSV Eindhoven | 1:2 |
| 27-09-25 20:00 | Heracles Almelo | Sparta Roterdão | 3:0 |
| 28-09-25 11:15 | NEC Nijmwegen | AZ Alkmaar | 2:1 |
| 28-09-25 13:30 | FC Groningen | Feyenoord Rotterdão | 0:1 |
| 28-09-25 13:30 | FC Utrecht | SC Heerenveen | 2:2 |
| 28-09-25 15:45 | Telstar | Go Ahead Eagles Deventer | 4:2 |